There are several classes that can use talismans: Demonologist , Tempest of Set , Priest of Mitra , Necromancer , Herald of Xotli and Dark Templar . As most of these classes are Mages and Priests, most talismans have Intelligence and/or Magic Damage stats to enhance spells in healing and damage, while the talismans with combat rating and Strength are only used by Dark Templars . There are also talismans that are useful for all classes, as they enhance Constitution, Mana, Hit Rating, Protection, Fatality Rating, etc.
Some talismans can only be equipped in Off-Hand, while other can be equipped in both Main Hand and off-hand making it possible to Dual Wield two talismans. The possible combination of talismans and weapons are with a Dagger, a One-Handed Blunt or a One-Handed Edged.